Research summary
Collaborative research links oncogenic TRIM37 to chemoresistance and metastatic behavior in TNBC models.
Study context
TRIM37 in breast-cancer outcomes
How do TRIM37 activity and variation relate to difficult breast-cancer outcomes?
How it was studied
The studies use the distinct model systems, molecular assays and population analyses described in their respective articles. Their claims should not be merged into one causal chain.
Selected findings
- The Cancer Research article links oncogenic TRIM37 to chemoresistance and metastatic phenotypes in TNBC models.
- EMBO Reports examines an rs57141087 association and functional context in Black women with TNBC.
Collaborative, coauthored research. Population associations and experimental mechanisms require their original study boundaries.
Authors
Cite this work
Piotr Przanowski, Song Lou, Rachisan Djiake Tihagam, Tanmoy Mondal, Caroline Conlan, Gururaj Shivange, Ilyas Saltani, Chandrajeet Singh, Kun Xing, Benjamin B Morris, Marty W Mayo, Luis Teixeira, Jacqueline Lehmann-Che, Jogender Tushir-Singh, Sanchita Bhatnagar (2020). Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer. Cancer research, 4791-4804. https://doi.org/10.1158/0008-5472.can-20-1459