Research summary
An interdisciplinary study tests microRNA-dependent regulation of X inactivation in Rett syndrome models.
Study context
X-chromosome reactivation in Rett research
Can altering microRNA-dependent X-inactivation control improve the phenotype in experimental Rett systems?
How it was studied
The paper studies microRNA-dependent control and phenotype measures in its reported experimental systems. Consult its full text for model- and intervention-specific details.
Selected findings
- The publication reports targeting microRNA-dependent X-inactivation control.
- The title and study describe improved Rett-related phenotype in experimental settings, not an established patient treatment.
Preclinical and interdisciplinary; it is not a clinical Rett therapy and does not establish Dr. Tushir-Singh as sole lead of the program.
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Authors
Cite this work
Song Lou, Rachisan DJiake Tihagam, Urszula N Wasko, Zaffar Equbal, Sanjay Venkatesan, Klaudia Braczyk, Piotr Przanowski, Bon Il Koo, Ilyas Saltani, Arjun Tushir Singh, Shibi Likhite, Samantha Powers, George M P R Souza, Robert A Maxwell, Jun Yu, Lihua J Zhu, Mark Beenhakker, Stephen B G Abbott, Zhipeng Lu, Michael R Green, Kathrin C Meyer, Jogender Tushir-Singh, Sanchita Bhatnagar (2025). Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype. Nature communications, 6169. https://doi.org/10.1038/s41467-025-61092-7